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Efficient Homogeneous Catalytic Hydrogenation of Esters to Alcohols
Author(s) -
Zhang Jing,
Leitus Gregory,
BenDavid Yehoshoa,
Milstein David
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200503771
Subject(s) - homogeneous , ruthenium , catalysis , ligand (biochemistry) , catalytic hydrogenation , chemistry , homogeneous catalysis , noyori asymmetric hydrogenation , combinatorial chemistry , organic chemistry , polymer chemistry , physics , biochemistry , thermodynamics , receptor
With open arms : A ruthenium PNN complex (see scheme) catalyzes the hydrogenation of esters in high yields under neutral conditions. The analogous PNP complex is less active. A mechanism is proposed based on the hemilabile nature of the PNN ligand which allows a vacant site to be created by decoordination of the CH 2 NEt 2 arm.