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Nonribosomal Peptide Biosynthesis: Point Mutations and Module Skipping Lead to Chemical Diversity
Author(s) -
Wenzel Silke C.,
Meiser Peter,
Binz Tina M.,
Mahmud Taifo,
Müller Rolf
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200503737
Subject(s) - nonribosomal peptide , biosynthesis , computational biology , peptide , mutant , biology , biochemistry , computer science , chemistry , gene
Big effects from small changes : In a comparative analysis of the nonribosomal peptide synthetases (NRPSs) from the biosynthetic pathways of two highly related myxobacterial lipopeptides, module skipping and point mutations are directly correlated to structural variations in these natural products. The skipping process during myxochromide S biosynthesis was characterized biochemically and represents the first example of a module skipping in NRPS systems.