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Asymmetric Organocatalytic Henry Reaction
Author(s) -
Marcelli Tommaso,
van der Haas Richard N. S.,
van Maarseveen Jan H.,
Hiemstra Henk
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200503724
Subject(s) - nitroaldol reaction , chemistry , organocatalysis , enantioselective synthesis , catalysis , organic chemistry
The nitroaldol (Henry) reaction between aromatic aldehydes and nitromethane can be carried out in high yields and enantiomeric excess by using a novel Cinchona ‐derived thiourea catalyst. Hydrogen‐bond donors at the C6′ position in these organocatalysts are shown to induce preferential formation of one enantiomer.