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Screening of a Supramolecular Catalyst Library in the Search for Selective Catalysts for the Asymmetric Hydrogenation of a Difficult Enamide Substrate
Author(s) -
Jiang XiaoBin,
Lefort Laurent,
Goudriaan P. Elsbeth,
de Vries André H. M.,
van Leeuwen Piet W. N. M.,
de Vries Johannes G.,
Reek Joost N. H.
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200503663
Subject(s) - catalysis , denticity , porphyrin , supramolecular chemistry , chemistry , combinatorial chemistry , substrate (aquarium) , supramolecular catalysis , asymmetric hydrogenation , enantioselective synthesis , selectivity , stereochemistry , organic chemistry , molecule , metal , oceanography , geology
Bindings for libraries : Large numbers of bidentate ligands have been formed from two monodentate ligands (one based on zinc( II ) porphyrin and the other on a substituted phosphane) by using high‐throughput methods combined with self‐assembly principles. The library provided a Rh catalyst that hydrogenates the enamide 1 with the highest enantioselectivity known to date.