Screening of a Supramolecular Catalyst Library in the Search for Selective Catalysts for the Asymmetric Hydrogenation of a Difficult Enamide Substrate | Zendy

Jiang XiaoBin | Zendy; Lefort Laurent | Zendy; Goudriaan P. Elsbeth | Zendy; de Vries André H. M. | Zendy; van Leeuwen Piet W. N. M. | Zendy; de Vries Johannes G. | Zendy; Reek Joost N. H. | Zendy

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Screening of a Supramolecular Catalyst Library in the Search for Selective Catalysts for the Asymmetric Hydrogenation of a Difficult Enamide Substrate

Author(s) -

Jiang XiaoBin,

Lefort Laurent,

Goudriaan P. Elsbeth,

de Vries André H. M.,

van Leeuwen Piet W. N. M.,

de Vries Johannes G.,

Reek Joost N. H.

Publication year - 2006

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200503663

Subject(s) - catalysis , denticity , porphyrin , supramolecular chemistry , chemistry , combinatorial chemistry , substrate (aquarium) , supramolecular catalysis , asymmetric hydrogenation , enantioselective synthesis , selectivity , stereochemistry , organic chemistry , molecule , metal , oceanography , geology

Bindings for libraries : Large numbers of bidentate ligands have been formed from two monodentate ligands (one based on zinc( II ) porphyrin and the other on a substituted phosphane) by using high‐throughput methods combined with self‐assembly principles. The library provided a Rh catalyst that hydrogenates the enamide 1 with the highest enantioselectivity known to date.

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