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Droplet‐Based DNA Purification in a Magnetic Lab‐on‐a‐Chip
Author(s) -
Lehmann Ulrike,
Vandevyver Caroline,
Parashar Virendra K.,
Gijs Martin A. M.
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200503624
Subject(s) - merge (version control) , magnetic bead , lab on a chip , chip , genomic dna , dna , magnetic separation , raw material , materials science , nanotechnology , microfluidics , magnetic nanoparticles , chromatography , chemistry , computer science , parallel computing , biochemistry , organic chemistry , nanoparticle , metallurgy , telecommunications
Merge, mix, split, and transport are the main manipulation steps used for on‐chip droplet‐based DNA purification (see figure). The system is able to extract genomic material from dilute raw cell samples by using the actuation of magnetic microparticles within the droplets through a matrix of coils.