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Total Synthesis of (±)‐Merrilactone A
Author(s) -
Mehta Goverdhan,
Singh S. Robindro
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200503618
Subject(s) - regioselectivity , cyclopentene , content (measure theory) , computer science , information retrieval , chemistry , organic chemistry , mathematics , mathematical analysis , catalysis
Merrily, merrily : A total synthesis of the pentacyclic sesquiterpenoid merrilactone A starting from 2,3‐dimethyl‐2‐cyclopentene‐1,4‐dione has been achieved with good stereo‐ and regioselectivity. Merrilactone A exhibits impressive neurotrophic activity and may be important for the development of therapeutic drugs for neurodegenerative disorders.