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From Polymer to Size‐Defined Oligomers: An Expeditious Route for the Preparation of Chondroitin Oligosaccharides
Author(s) -
Lopin Chrystel,
Jacquinet JeanClaude
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200503551
Subject(s) - chondroitin sulfate , hydrolysis , yield (engineering) , chondroitin sulphate , polymer , chemistry , chondroitin , combinatorial chemistry , computer science , organic chemistry , biochemistry , materials science , glycosaminoglycan , metallurgy
A synthetic short cut : Controlled acid hydrolysis of polymeric chondroitin sulfate affords a tailor‐made disaccharidic fragment in good yield. This compound acts as a versatile starting material for the efficient construction of size‐defined chondroitin oligosaccharides (see scheme, n =1, 2, 3, etc.) and precursors of various sulfo forms.