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Dissecting the Behavior of a Promiscuous Solvate Former
Author(s) -
Price Christopher P.,
Glick Gary D.,
Matzger Adam J.
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200503533
Subject(s) - derivative (finance) , content (measure theory) , crystal (programming language) , computer science , information retrieval , chemistry , advertising , business , mathematics , programming language , mathematical analysis , finance
Take any partner : Benzodiazepine derivative Bz‐423 (see picture) can be described as an indiscriminate solvate former as it cocrystallizes with a diverse array of small molecules. This behavior was investigated by analysis of the packing efficiency of these crystal forms relative to that of unsolvated Bz‐423 and an appropriate model compound.