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Widely Applicable Pd‐Catalyzed trans ‐Selective Monoalkylation of Unactivated 1,1‐Dichloro‐1‐alkenes and Pd‐Catalyzed Second Substitution for the Selective Synthesis of E or Z Trisubstituted Alkenes
Author(s) -
Tan Ze,
Negishi Eiichi
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200503519
Subject(s) - substitution (logic) , catalysis , alkylation , chemistry , substitution reaction , combinatorial chemistry , medicinal chemistry , stereochemistry , organic chemistry , computational chemistry , computer science , programming language
Double substitution : The first selective and widely applicable method for a stepwise alkylation of 1,1‐dichloro‐1‐alkenes involving a cross‐coupling double substitution using Pd‐catalysis has been developed. This method provides an efficient and highly selective route for the synthesis of E or Z trisubstituted alkenes. dpephos=bis( o ‐diphenylphosphanylphenylether).