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A Striking Periodicity of the cis / trans Isomerization of Proline Imide Bonds in Cyclic Disulfide‐Bridged Peptides
Author(s) -
Shi Tiesheng,
Spain Stephen M.,
Rabenstein Dallas L.
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200503470
Subject(s) - isomerization , imide , disulfide bond , chemistry , peptide , cyclic peptide , sequence (biology) , stereochemistry , proline , population , crystallography , amino acid , polymer chemistry , biochemistry , catalysis , demography , sociology
cis persists : The population of the cis conformation of the Cys–Pro imide bond of the cyclic disulfide form of peptides of the sequence Ac‐Cys‐Pro‐(Xaa) m ‐Cys‐NH 2 (Xaa=Phe, Ala) ranges from 9.3 to 76.9 % and shows a striking periodic dependence on the number of residues in the peptide.