Premium
Ruthenium Half‐Sandwich Complexes Bound to Protein Kinase Pim‐1
Author(s) -
Debreczeni Judit É.,
Bullock Alex N.,
Atilla G. Ekin,
Williams Douglas S.,
Bregman Howard,
Knapp Stefan,
Meggers Eric
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200503468
Subject(s) - ruthenium , chemistry , protein kinase a , binding site , stereochemistry , combinatorial chemistry , biophysics , phosphorylation , biochemistry , catalysis , biology
Keeping in shape with half a sandwich : The structure of a picomolar organoruthenium inhibitor bound to the ATP‐binding site of the protein kinase Pim‐1 (see picture) demonstrates that the ruthenium center has solely a structural role in organizing the organic ligands in the three‐dimensional receptor space, thus yielding a structure that is complementary in shape and functional group presentation to the active site of Pim‐1.