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Amino Acid Derived Macrocycles—An Area Driven by Synthesis or Application?
Author(s) -
Gibson Susan E.,
Lecci Cristina
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200503428
Subject(s) - chemistry , nanotechnology , amino acid , combinatorial chemistry , function (biology) , membrane , molecule , materials science , organic chemistry , biochemistry , biology , evolutionary biology
The synthesis, structure, and physical properties of macrocycles have fascinated chemists for many years. Their inherent properties make them useful in areas as diverse as ion transport across membranes, development of new antibiotics, and catalysis. In this Review, the authors examine the chemistry of macrocycles containing non‐peptidic amino acid derived molecules; the analysis is discussed in terms of function, rather than structure or synthesis. It is revealed that the diverse and imaginative structures created by synthetic chemists are not being fully exploited in application‐driven endeavors.