Large‐Scale Synthesis of H‐Antigen Oligosaccharides by Expressing  Helicobacter pylori  α1,2‐Fucosyltransferase in Metabolically Engineered  Escherichia coli  Cells | Zendy

Drouillard Sophie | Zendy; Driguez Hugues | Zendy; Samain Eric | Zendy

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Large‐Scale Synthesis of H‐Antigen Oligosaccharides by Expressing Helicobacter pylori α1,2‐Fucosyltransferase in Metabolically Engineered Escherichia coli Cells

Author(s) -

Drouillard Sophie,

Driguez Hugues,

Samain Eric

Publication year - 2006

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200503427

Subject(s) - fucosyltransferase , escherichia coli , heterologous , lactose , antigen , microbiology and biotechnology , chemistry , biochemistry , recombinant dna , biology , gene , genetics

Sugar production : A microbiological method has been developed for the production of fucosyl α1,2‐linked carbohydrates from lactose. The syntheses of 2′‐fucosyllactose and lacto‐ N ‐neofucopentaose‐1 (see structure), which contain the H‐2 antigen (Fucα‐2Galβ‐4R), were achieved by cultivating Escherichia coli strains that overexpressed the appropriate heterologous genes.

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