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Lydiamycins A–D: Cyclodepsipetides with Antimycobacterial Properties
Author(s) -
Huang Xueshi,
Roemer Ernst,
Sattler Isabel,
Moellmann Ute,
Christner Arnulf,
Grabley Susanne
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200503381
Subject(s) - antimycobacterial , stereochemistry , chemistry , strain (injury) , derivative (finance) , fermentation , antibiotics , ring (chemistry) , lactone , cytotoxic t cell , combinatorial chemistry , biochemistry , biology , mycobacterium tuberculosis , organic chemistry , in vitro , tuberculosis , medicine , pathology , financial economics , economics , anatomy
Out of the brew! Four new antibiotics were isolated from a fermentation broth of Steptomyces lydicus (strain HKI0343). The 13‐membered‐ring peptides (see formula, XY: CH 2 NH, CHNH; R1, R2: H, OH) are cyclized through a lactone function at serine and also contain the nonproteinogenic amino acid piperazic acid (or a derivative thereof). The peptides show promising activity against various mycobacteria without being cytotoxic.