Dimerization of Lithiated Terminal Aziridines | Zendy

Hodgson David M. | Zendy; Miles Steven M. | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Dimerization of Lithiated Terminal Aziridines

Author(s) -

Hodgson David M.,

Miles Steven M.

Publication year - 2006

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200503303

Subject(s) - enantiopure drug , terminal (telecommunication) , olefin fiber , computer science , combinatorial chemistry , chemistry , scheme (mathematics) , core (optical fiber) , stereochemistry , enantioselective synthesis , catalysis , organic chemistry , mathematics , computer network , mathematical analysis , telecommunications

Let's get together : Dimerization of enantiopure terminal aziridines by lithiation gives efficiently N‐protected 2‐ene‐1,4‐diamines with complete selectivity for the E olefin (see scheme). The usefulness of the method was demonstrated in a concise synthesis of ( R , S , S , R )‐2,5‐diamino‐1,6‐diphenylhexane‐3,4‐diol, the core unit of many extremely potent HIV protease inhibitors and also asymmetric catalysts.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research