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Self‐Assembled Nanoreactors as Highly Active Catalysts in the Hydrolytic Kinetic Resolution (HKR) of Epoxides in Water
Author(s) -
Rossbach Benjamin M.,
Leopold Kerstin,
Weberskirch Ralf
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200503291
Subject(s) - kinetic resolution , chemistry , nanoreactor , hydrolysis , amphiphile , ethylenediamine , catalysis , copolymer , polymer chemistry , organic chemistry , enantioselective synthesis , polymer
Co III (salen) complexes have been immobilized on amphiphilic block copolymers, which self‐assemble in water to give micellar aggregates with a hydrophobic Co(salen) core and a water‐soluble shell (see picture). These aggregates were used to catalyze the hydrolytic kinetic resolution (HKR) of racemic aromatic epoxides over four consecutive cycles and gave the epoxides in up to 99 % ee. H 2 salen= N , N ′‐bis(salicylidene)ethylenediamine.