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Laser‐Induced Acoustic Desorption Mass Spectrometry of Single Bioparticles
Author(s) -
Peng WenPing,
Yang YiChang,
Kang MingWei,
Tzeng YanKai,
Nie Zongxiu,
Chang HuanCheng,
Chang Wen,
Chen ChungHsuan
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200503271
Subject(s) - mass spectrometry , laser , quadrupole , ion trap , quadrupole mass analyzer , chemistry , desorption , analytical chemistry (journal) , materials science , optics , atomic physics , physics , chromatography , adsorption , organic chemistry
Single charged bioparticles such as viruses, bacteria, and mammalian whole cells have been successfully desorbed by laser‐induced acoustic waves and analyzed with a quadrupole ion‐trap mass spectrometer (see picture). This approach offers a high sensitivity of detection and good accuracy of the mass measurement. The capability to measure the mass of an entire cell has broad potential in biomedical applications.