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Direct Carbon–Carbon Bond Formation from Alcohols and Active Methylenes, Alkoxyketones, or Indoles Catalyzed by Indium Trichloride
Author(s) -
Yasuda Makoto,
Somyo Toshio,
Baba Akio
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200503263
Subject(s) - chemistry , catalysis , carbon fibers , alkylation , organic chemistry , indium , materials science , composite number , composite material
The unsalted variety : The direct coupling reaction of alcohols with active methylenes, alkoxyketones, or indoles catalyzed by InCl 3 proceeds without the formation of metal salts (see scheme). As H 2 O is the only by‐product of this system, the alkylated products are easily isolated in pure form, and the reaction is suitable for large‐scale synthesis.