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Highly Enantioselective Addition of Diphenylzinc to Aliphatic and Aromatic Aldehydes Catalyzed by a Readily Available H 8 ‐Binol Derivative
Author(s) -
Qin YingChuan,
Pu Lin
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200503206
Subject(s) - enantioselective synthesis , catalysis , aryl , chemistry , derivative (finance) , organic chemistry , alkyl , combinatorial chemistry , medicinal chemistry , business , finance
All sorts of aldehydes 2 (R=aryl, vinyl, branched, and linear alkyl) undergo the highly enantioselective addition of diphenylzinc ( 1 ) in the presence of catalytic ( S )‐ 4 to give α‐substituted benzyl alcohols 3 in high yields. In contrast to previous catalysts, no additive is required, the reaction is carried out at room temperature, and the reaction is equally effective with linear aldehydes.