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Molecular‐Recognition Characteristics of SAM‐Binding Riboswitches
Author(s) -
Lim Jinsoo,
Winkler Wade C.,
Nakamura Shingo,
Scott Valerie,
Breaker Ronald R.
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200503198
Subject(s) - riboswitch , molecular recognition , computational biology , rna , biology , genetics , chemistry , non coding rna , molecule , gene , organic chemistry
A series of analogues of S ‐adenosylmethionine (SAM) have been used to examine the molecular‐recognition characteristics of an RNA genetic element or riboswitch. Biochemical assays indicate that the riboswitch of the SAM‐I class is highly selective for SAM and exhibits a pattern of molecular recognition that is distinct from that of the SAM‐II class of riboswitches.