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Catalytic Decomposition of Simulants for Chemical Warfare V Agents: Highly Efficient Catalysis of the Methanolysis of Phosphonothioate Esters
Author(s) -
Melnychuk Stephanie A.,
Neverov Alexei A.,
Brown R. Stan
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200503182
Subject(s) - chemistry , hydrolysis , catalysis , acylation , transesterification , organic chemistry , combinatorial chemistry , medicinal chemistry
As good as the original : Extremely effective methanolysis of phosphonothioates using metal‐containing systems (e.g., 1 ) was achieved. The catalytic methanolysis of a SCH 2 CH 2 NEt 2 derivative, an analogue of the organophosphorus chemical warfare material VX, was predicted, and the catalyzed methanolysis of S‐ (3,5‐dichlorophenyl) O ‐ethyl methylphosphonothioate was shown to involve a concerted displacement of the aryl thioate (transition state 2 ).