Catalytic Decomposition of Simulants for Chemical Warfare V Agents: Highly Efficient Catalysis of the Methanolysis of Phosphonothioate Esters | Zendy

Melnychuk Stephanie A. | Zendy; Neverov Alexei A. | Zendy; Brown R. Stan | Zendy

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Catalytic Decomposition of Simulants for Chemical Warfare V Agents: Highly Efficient Catalysis of the Methanolysis of Phosphonothioate Esters

Author(s) -

Melnychuk Stephanie A.,

Neverov Alexei A.,

Brown R. Stan

Publication year - 2006

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200503182

Subject(s) - chemistry , hydrolysis , catalysis , acylation , transesterification , organic chemistry , combinatorial chemistry , medicinal chemistry

As good as the original : Extremely effective methanolysis of phosphonothioates using metal‐containing systems (e.g., 1 ) was achieved. The catalytic methanolysis of a SCH 2 CH 2 NEt 2 derivative, an analogue of the organophosphorus chemical warfare material VX, was predicted, and the catalyzed methanolysis of S‐ (3,5‐dichlorophenyl) O ‐ethyl methylphosphonothioate was shown to involve a concerted displacement of the aryl thioate (transition state 2 ).

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