Diagnostics of Single Base‐Mismatch DNA Hybridization on Gold Nanoparticles by Using the Hyper‐Rayleigh Scattering Technique | Zendy

Ray Paresh Chandra | Zendy

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Diagnostics of Single Base‐Mismatch DNA Hybridization on Gold Nanoparticles by Using the Hyper‐Rayleigh Scattering Technique

Author(s) -

Ray Paresh Chandra

Publication year - 2006

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200503114

Subject(s) - rayleigh scattering , oligonucleotide , dna , dna–dna hybridization , scattering , base pair , colloidal gold , chemistry , microbiology and biotechnology , materials science , nanoparticle , nanotechnology , biophysics , analytical chemistry (journal) , optics , biology , physics , chromatography , biochemistry

Highly sensitive : The hyper‐Rayleigh Scattering (HRS) technique has been used to achieve the ultrasensitive detection of single base‐pair mismatches in oligonucleotide strands without any modification of DNA. A very distinct HRS intensity change is observed after hybridization even at the concentration of 10‐nanomolar probe single‐stranded DNA.

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