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Stabilization of the DNA I‐Motif Structure by Incorporation of 3′‐ S ‐Phosphorothiolate Linkages
Author(s) -
Brazier John A.,
Fisher Julie,
Cosstick Richard
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200503110
Subject(s) - motif (music) , cytosine , dna , structural motif , sequence motif , chemistry , stereochemistry , computational biology , biology , biochemistry , philosophy , aesthetics
A stable i : The i‐motif is a unique, four‐stranded DNA structure associated with cytosine‐rich sequences at the ends of human chromosomes. This is the first report of an i‐motif stabilized by a deoxycytidine analogue and demonstrates the importance of the sugar conformation in the i‐motif structure.