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Label‐Free Biosensing with Hydrogel Microlenses
Author(s) -
Kim Jongseong,
Singh Neetu,
Lyon L. Andrew
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200503102
Subject(s) - microlens , biosensor , phosphate buffered saline , materials science , self healing hydrogels , antigen , nanotechnology , bioassay , chemistry , biophysics , optics , chromatography , biology , polymer chemistry , lens (geology) , immunology , physics , genetics
Soft lenses : Reversible antibody–antigen cross‐links at the surface of a hydrogel microlens allow focal tuning of the microlens in response to soluble antigens (see picture; PBS=phosphate‐buffered saline) to form the basis of a label‐free biosensor/bioassay technique, whose sensitivity can be tuned by controlling the number of cross‐links required to effect a specific swelling response.