Label‐Free Biosensing with Hydrogel Microlenses | Zendy

Kim Jongseong | Zendy; Singh Neetu | Zendy; Lyon L. Andrew | Zendy

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Label‐Free Biosensing with Hydrogel Microlenses

Author(s) -

Kim Jongseong,

Singh Neetu,

Lyon L. Andrew

Publication year - 2006

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200503102

Subject(s) - microlens , biosensor , phosphate buffered saline , materials science , self healing hydrogels , antigen , nanotechnology , bioassay , chemistry , biophysics , optics , chromatography , biology , polymer chemistry , lens (geology) , immunology , physics , genetics

Soft lenses : Reversible antibody–antigen cross‐links at the surface of a hydrogel microlens allow focal tuning of the microlens in response to soluble antigens (see picture; PBS=phosphate‐buffered saline) to form the basis of a label‐free biosensor/bioassay technique, whose sensitivity can be tuned by controlling the number of cross‐links required to effect a specific swelling response.

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