Premium
A Mimicry of Primary Amines by Bis‐Secondary Diamines as Components in the Ugi Four‐Component Reaction
Author(s) -
Giovenzana Giovanni Battista,
Tron Gian Cesare,
Di Paola Stefano,
Menegotto Ivan Guglielmo,
Pirali Tracey
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200503095
Subject(s) - ugi reaction , primary (astronomy) , amine gas treating , component (thermodynamics) , yield (engineering) , chemistry , combinatorial chemistry , protein primary structure , stereochemistry , organic chemistry , isocyanide , materials science , biochemistry , peptide sequence , physics , metallurgy , astronomy , thermodynamics , gene
Splitting the amine! The Ugi four‐component reaction (Ugi 4CR) relies on the presence of a component with a primary amino group. This protocol has been modified by “splitting” the primary amine into two secondary amines. The resulting variant of the Ugi 4CR proceeds with good to excellent yield and widens the versatility of the original multicomponent reaction by enabling variation of the molecular backbone.