Spatially Encoded Single‐Bead Biginelli Synthesis in a Microstructured Silicon Array | Zendy

Groß G. Alexander | Zendy; Mayer Günther | Zendy; Albert Jens | Zendy; Riester Daniel | Zendy; Osterodt Jens | Zendy; Wurziger Hanns | Zendy; Schober Andreas | Zendy

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Spatially Encoded Single‐Bead Biginelli Synthesis in a Microstructured Silicon Array

Author(s) -

Groß G. Alexander,

Mayer Günther,

Albert Jens,

Riester Daniel,

Osterodt Jens,

Wurziger Hanns,

Schober Andreas

Publication year - 2006

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200503041

Subject(s) - microreactor , bead , wafer , silicon , materials science , nanotechnology , optoelectronics , chemistry , catalysis , organic chemistry , composite material

Miniature labs : A microstructured silicon wafer was used as a microreactor array for single‐bead synthesis on a nanovolume scale. Products were prepared by combinatorial synthesis and spatially encoded by their position in the array. Three‐component Biginelli condensations were carried out at 100 °C for 14 h and therefore required the development of a specially sealed reactor device.

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