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Spatially Encoded Single‐Bead Biginelli Synthesis in a Microstructured Silicon Array
Author(s) -
Groß G. Alexander,
Mayer Günther,
Albert Jens,
Riester Daniel,
Osterodt Jens,
Wurziger Hanns,
Schober Andreas
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200503041
Subject(s) - microreactor , bead , wafer , silicon , materials science , nanotechnology , optoelectronics , chemistry , catalysis , organic chemistry , composite material
Miniature labs : A microstructured silicon wafer was used as a microreactor array for single‐bead synthesis on a nanovolume scale. Products were prepared by combinatorial synthesis and spatially encoded by their position in the array. Three‐component Biginelli condensations were carried out at 100 °C for 14 h and therefore required the development of a specially sealed reactor device.