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DNA Recognition with Large Calixarene Dimers
Author(s) -
Zadmard Reza,
Schrader Thomas
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200502946
Subject(s) - calixarene , dna , psychology , chemistry , biochemistry , organic chemistry , molecule
Feeling groovy : A large dimeric calix[4]arene hexaaniline binds selectively to double‐stranded DNA and especially RNA with submicromolar K D values. The picture shows a simulation of the complex between a 12‐base‐pair B‐DNA (green and blue) and an anilinocalixarene dimer (red), which fits snugly into the major groove. Several physical and spectroscopic characteristics strongly indicate insertion into the major groove.