Premium
Evidence for the Formation and Structure of Palladacycles during Pd‐Catalyzed CN Bond Formation with Catalysts Derived from Bulky Monophosphinobiaryl Ligands
Author(s) -
Strieter Eric R.,
Buchwald Stephen L.
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200502927
Subject(s) - catalysis , chemistry , combinatorial chemistry , stereochemistry , palladium , medicinal chemistry , polymer chemistry , organic chemistry
The structural origins of the differences in catalytic activity observed between catalysts containing 2′‐substituted and 2′,6′‐disubstituted biaryl monophosphane ligands for a Pd‐catalyzed CN bond‐forming reaction are discussed. It is shown that palladacycle formation is avoided and optimal catalyst activity is achieved through the use of the 2′,6′‐disubstituted ligands. ( t Am= tert ‐amyl, dppe=1,2‐bis(diphenylphosphanyl)ethane).