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Ferrocene‐Mediated Proton‐Coupled Electron Transfer in a Series of Ferrocifen‐Type Breast‐Cancer Drug Candidates
Author(s) -
Hillard Elizabeth,
Vessières Anne,
Thouin Laurent,
Jaouen Gérard,
Amatore Christian
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200502925
Subject(s) - antiestrogen , ferrocene , cytotoxicity , breast cancer , drug , chemistry , electron transfer , pyridine , cancer , tamoxifen , pharmacology , medicine , medicinal chemistry , photochemistry , in vitro , biochemistry , electrode , electrochemistry
A double‐barreled approach : The addition of ferrocene to an antiestrogen drug skeleton was found to induce cytotoxicity towards breast‐cancer cells that are resistant to the common antiestrogen drug. The efficacy of this drug has been related to the proton‐coupled electron transfer observed in the presence of pyridine as a base (see picture).