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The Total Synthesis of the Fungal Metabolite Diversonol
Author(s) -
Nising Carl F.,
Ohnemüller née Schmid Ulrike K.,
Bräse Stefan
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200502913
Subject(s) - metabolite , total synthesis , domino , aldol reaction , aldehyde , aldol condensation , salicylic acid , chemistry , stereochemistry , organic chemistry , biochemistry , catalysis
Mission accomplished . The fungal metabolite diversonol has been synthesized for the first time. A key step in the total synthesis was the domino oxa‐Michael–aldol condensation of salicylic aldehyde 1 and 4‐hydroxycyclohexenone ( 2 ) that afforded the tricyclic scaffold of the target compound.