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Mechanistic Studies on the Conversion of Arylamines into Arylnitro Compounds by Aminopyrrolnitrin Oxygenase: Identification of Intermediates and Kinetic Studies
Author(s) -
Lee Jungkul,
Zhao Huimin
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200502903
Subject(s) - dehydrogenation , chemistry , oxygenase , substrate (aquarium) , kinetic energy , catalysis , computational chemistry , combinatorial chemistry , organic chemistry , enzyme , physics , quantum mechanics , oceanography , geology
Rieske business! The Rieske N ‐oxygenase, aminopyrrolnitrin oxygenase (PrnD), catalyzes the unusual oxidation of arylamines to arylnitro compounds. Kinetic analysis has confirmed that PrnD catalyzes the conversion of the substrate pABA (4‐aminobenzylamine) through at least three consecutive reactions: two monooxygenation steps and one dehydrogenation step (see scheme).