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Ordered Multistep Synthesis in a Single Solution Directed by DNA Templates
Author(s) -
Snyder Thomas M.,
Liu David R.
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200502879
Subject(s) - template , tripeptide , dna , reactivity (psychology) , molar concentration , chemistry , combinatorial chemistry , materials science , peptide , nanotechnology , biochemistry , organic chemistry , medicine , alternative medicine , pathology
A triolefin and a tripeptide were prepared in a single solution (see scheme) by ordered multistep synthesis. Temperature‐sensitive variations in DNA secondary structure were used to orchestrate a series of effective molarity changes among four reactants of comparable intrinsic reactivity, resulting predominantly in one ordered product out of many possibilities. This approach mimics the selective control of effective molarity at precise moments during biosynthesis.