Premium
Studies into Asymmetric Catalysis of the Nozaki–Hiyama Allenylation
Author(s) -
Inoue Masahiro,
Nakada Masahisa
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200502871
Subject(s) - enantioselective synthesis , chemistry , trimethylsilyl , catalysis , organic chemistry , ligand (biochemistry) , combinatorial chemistry , biochemistry , receptor
From aldehydes to allenic alcohols : Studies into the asymmetric catalysis of the Nozaki–Hiyama allenylation are described. Ligand 1 a is effective for the enantioselective allenylations of various aldehydes, with the generation of products with ee values ranging from 72–83 %. The products can be easily desilylated or used as allenylsilanes. DIPEA=diisopropylethylamine, DMI=1,3‐dimethyl‐2‐imidazolidinone, DMS=dimethylsilyl, TMS=trimethylsilyl.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom