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Undressing of Phosphine Gold( I ) Complexes as Irreversible Inhibitors of Human Disulfide Reductases
Author(s) -
Urig Sabine,
FritzWolf Karin,
Réau Régis,
HeroldMende Christel,
Tóth Katalin,
DavioudCharvet Elisabeth,
Becker Katja
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200502756
Subject(s) - phosphine , redox , glutathione , chemistry , enzyme , disulfide bond , biochemistry , dna , stereochemistry , metal , combinatorial chemistry , biophysics , inorganic chemistry , organic chemistry , biology , catalysis
Redox‐based chemotherapy : The irreversible inhibition of human glutathione reductase results in a unique S‐Au I ‐S coordination, which was determined crystallographically. The chemotherapeutic potential of phosphine–metal complexes was probed by kinetic analysis of the fast and effective inhibition of redox enzymes as well as by DNA‐interaction studies and cell‐proliferation tests.