Synthetic Substrates for an Endoplasmic Reticulum Protein‐Folding Sensor, UDP‐Glucose: Glycoprotein Glucosyltransferase | Zendy

Totani Kiichiro | Zendy; Ihara Yoshito | Zendy; Matsuo Ichiro | Zendy; Koshino Hiroyuki | Zendy; Ito Yukishige | Zendy

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Synthetic Substrates for an Endoplasmic Reticulum Protein‐Folding Sensor, UDP‐Glucose: Glycoprotein Glucosyltransferase

Author(s) -

Totani Kiichiro,

Ihara Yoshito,

Matsuo Ichiro,

Koshino Hiroyuki,

Ito Yukishige

Publication year - 2005

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200502723

Subject(s) - glucosyltransferase , calnexin , calreticulin , endoplasmic reticulum , glycoprotein , chemistry , mannose , biochemistry , glucosamine , substrate (aquarium) , golgi apparatus , glycan , microbiology and biotechnology , enzyme , biology , ecology

Quality control : UDP‐glucose:glycoprotein glucosyltransferase (UGGT) works as the folding sensor in glycoprotein quality control. It glucosylates the Man9GlcNAc2 of misfolded glycoproteins to produce Glc1Man9GlcNAc2, which is a ligand of calnexin and calreticulin. The synthetic substrate Man9GlcNAc2‐MTX can be used for the quantitative analysis of UGGT. UDP=uridine 5′‐diphosphate, Glc= D ‐glucose, Man= D ‐mannose, GlcNAc= N ‐acetyl‐ D ‐glucosamine, MTX=methotrexate.

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