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Programmable Ligand‐Controlled Riboregulators
Author(s) -
Micura Ronald
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200502700
Subject(s) - modular design , aptamer , domain (mathematical analysis) , ligand (biochemistry) , computer science , computational biology , chemistry , nanotechnology , microbiology and biotechnology , biology , materials science , biochemistry , programming language , mathematics , receptor , mathematical analysis
A flexible platform for control of gene expression is represented by rationally designed antiswitches. These trans ‐acting riboregulators consist of an antisense domain and an aptamer domain. They are responsive to small ligands, modular, and fully tunable to target any gene of interest (see picture).