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Enantiodiscrimination and Enantiocontrol of Neutral and Cationic Pt II Complexes Bearing the Tropos Biphep Ligand: Application to Asymmetric Lewis Acid Catalysis
Author(s) -
Mikami Koichi,
Kakuno Hitomi,
Aikawa Kohsuke
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200502682
Subject(s) - enantiopure drug , chemistry , trifluoromethanesulfonate , enantiomer , cationic polymerization , ligand (biochemistry) , catalysis , enantiomeric excess , medicinal chemistry , lewis acids and bases , stereochemistry , enantioselective synthesis , organic chemistry , receptor , biochemistry
The stereochemically stable , enantiopure biphep–Pt complexes can be employed as an atropos asymmetric catalyst at 50 °C or below. Both enantiomeric forms of this complex can be obtained by using either the chiral diamine ( R )‐dabn or its diamide ( R )‐dabnTf followed by chirally controlled formation of the single biphep–Pt enantiomer at higher (>60 °C) temperatures (see scheme; Tf=trifluoromethanesulfonate).