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Enantioselective Aza‐Henry Reactions Assisted by Zn II and N ‐Methylephedrine
Author(s) -
Palomo Claudio,
Oiarbide Mikel,
Halder Rajkumar,
Laso Antonio,
López Rosa
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200502674
Subject(s) - nitromethane , nitroaldol reaction , amine gas treating , enantioselective synthesis , zinc , trifluoromethanesulfonate , chemistry , aldimine , medicinal chemistry , organic chemistry , catalysis
Hooray aza‐Henry! A combination of zinc triflate, an amine base, and (−)‐ N ‐methylephedrine (NME), which can be easily recovered and reused, leads to high enantioselectivities in the aza‐Henry reaction of N ‐Boc‐protected aldimines and nitromethane (see scheme; Boc= tert ‐butyloxycarbonyl).
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