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Construction of Quaternary Stereocenters by Efficient and Practical Conjugate Additions to α,β‐Unsaturated Ketones with a Chiral Organic Catalyst
Author(s) -
Wu Fanghui,
Li Hongming,
Hong Ran,
Deng Li
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200502658
Subject(s) - stereocenter , conjugate , catalysis , quaternary carbon , yield (engineering) , enantioselective synthesis , chemistry , organic chemistry , carbon fibers , combinatorial chemistry , mathematics , materials science , algorithm , mathematical analysis , metallurgy , composite number
Added value : The conjugate addition of cyclic or acyclic α‐substituted β‐ketoesters to α,β‐unsaturated ketones using a chiral organic catalyst ( 1 ) can be achieved with good enantioselectivity, diastereoselectivity, and yield. This asymmetric CC bond formation strategy provides a range of chiral building blocks 2 that contain an all‐carbon quaternary stereocenter.