Construction of Quaternary Stereocenters by Efficient and Practical Conjugate Additions to α,β‐Unsaturated Ketones with a Chiral Organic Catalyst | Zendy

Wu Fanghui | Zendy; Li Hongming | Zendy; Hong Ran | Zendy; Deng Li | Zendy

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Construction of Quaternary Stereocenters by Efficient and Practical Conjugate Additions to α,β‐Unsaturated Ketones with a Chiral Organic Catalyst

Author(s) -

Wu Fanghui,

Li Hongming,

Hong Ran,

Deng Li

Publication year - 2006

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200502658

Subject(s) - stereocenter , conjugate , catalysis , quaternary carbon , yield (engineering) , enantioselective synthesis , chemistry , organic chemistry , carbon fibers , combinatorial chemistry , mathematics , materials science , algorithm , mathematical analysis , metallurgy , composite number

Added value : The conjugate addition of cyclic or acyclic α‐substituted β‐ketoesters to α,β‐unsaturated ketones using a chiral organic catalyst ( 1 ) can be achieved with good enantioselectivity, diastereoselectivity, and yield. This asymmetric CC bond formation strategy provides a range of chiral building blocks 2 that contain an all‐carbon quaternary stereocenter.

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