Premium
Catalytic Enantioselective Cross‐Mannich Reaction of Aldehydes
Author(s) -
Marques Maria Manuel B.
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200502630
Subject(s) - enantioselective synthesis , mannich reaction , catalysis , chemistry , optically active , combinatorial chemistry , organic chemistry , stereoisomerism , aldehyde
A wide variety of optically active compounds as well as active compounds such as amino acid derivatives can be accessed by the cross‐Mannich reaction of aldehydes, particularly by the direct catalytic asymmetric version, in which CC bonds are formed. Remarkable advancements have been reported, including one‐pot, three‐component procedures with absolute stereocontrol and high yields (see example, NMP= N ‐methylpyrrolidine).