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Total Synthesis of Antigen Bacillus Anthracis Tetrasaccharide—Creation of an Anthrax Vaccine Candidate
Author(s) -
Werz Daniel B.,
Seeberger Peter H.
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200502615
Subject(s) - bacillus anthracis , anthrax vaccines , tetrasaccharide , microbiology and biotechnology , virology , biology , antigen , immunology , bacteria , biochemistry , genetics , immunization , polysaccharide , dna vaccination
Fighting Anthrax by recognizing its coat : The spores of Bacillus anthracis bear unique oligosaccharides on their surface for interaction with a host. These specific oligosaccharides may prove useful in the development of vaccines against this major biowarfare threat. The total synthesis of such a vaccine candidate (see picture, Pent=4‐pentenyl) is reported.