Total Synthesis of Antigen  Bacillus Anthracis  Tetrasaccharide—Creation of an Anthrax Vaccine Candidate | Zendy

Werz Daniel B. | Zendy; Seeberger Peter H. | Zendy

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Total Synthesis of Antigen Bacillus Anthracis Tetrasaccharide—Creation of an Anthrax Vaccine Candidate

Author(s) -

Werz Daniel B.,

Seeberger Peter H.

Publication year - 2005

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200502615

Subject(s) - bacillus anthracis , anthrax vaccines , tetrasaccharide , microbiology and biotechnology , virology , biology , antigen , immunology , bacteria , biochemistry , genetics , immunization , polysaccharide , dna vaccination

Fighting Anthrax by recognizing its coat : The spores of Bacillus anthracis bear unique oligosaccharides on their surface for interaction with a host. These specific oligosaccharides may prove useful in the development of vaccines against this major biowarfare threat. The total synthesis of such a vaccine candidate (see picture, Pent=4‐pentenyl) is reported.

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