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Crown Ether–Gramicidin Hybrid Ion Channels: Dehydration‐Assisted Ion Selectivity
Author(s) -
Pfeifer Jochen R.,
Reiß Philipp,
Koert Ulrich
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200502570
Subject(s) - selectivity , crown ether , ion , chemistry , gramicidin , ion channel , ether , organic chemistry , membrane , biochemistry , receptor , catalysis
Predictable ion selectivity is a major goal for the use of synthetic channels in biological systems. Gramicidin A ( gA ) is a suitable lead structure for the design of such channels. The crown ether– gA hybrid structure shown forms ion channels with a higher ion selectivity for K + than for Cs + .
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