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Construction of Molecular Logic Gates with a DNA‐Cleaving Deoxyribozyme
Author(s) -
Chen Xi,
Wang Yifei,
Liu Qiang,
Zhang Zhizhou,
Fan Chunhai,
He Lin
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200502511
Subject(s) - deoxyribozyme , ribonucleotide , dna , oligonucleotide , logic gate , computer science , dna computing , chemistry , computational biology , biology , biochemistry , nucleotide , gene , algorithm
A logical conclusion : DNA logic gates constructed by using a Cu 2+ ‐dependent DNA‐cleaving deoxyribozyme are as efficient as the relatively unstable ribonucleotide‐containing systems. The inputs (effectors), gates (deoxyribozymes), and outputs (substrates) are represented by chemically robust DNA oligonucleotides, which perform logic operations including “YES”, “NOT”, and “AND(A,NOT(B),NOT(C))” (see picture).