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Enantioselective α‐Fluorination of Carbonyl Compounds: Organocatalysis or Metal Catalysis?
Author(s) -
Pihko Petri M.
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200502425
Subject(s) - enantioselective synthesis , organocatalysis , chemistry , catalysis , organic chemistry , amine gas treating , combinatorial chemistry
Five ground‐breaking studies in enantioselective α‐fluorination of carbonyl compounds have been disclosed. Four describe the use of amine organocatalysts to promote the asymmetric fluorination of aldehydes, whereas the fifth describes a highly enantioselective fluorination of carbonyl compounds capable of two‐point binding (e.g. β‐ketoesters). NFSI= N‐ fluorobenzenesulfonimide.