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Controlled Autocatalytic Nitration of Phenol in a Microreactor
Author(s) -
Ducry Laurent,
Roberge Dominique M.
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200502387
Subject(s) - microreactor , nitration , autocatalysis , exothermic reaction , phenol , chemistry , chemical engineering , mixing (physics) , materials science , organic chemistry , process engineering , catalysis , engineering , physics , quantum mechanics
Scaled‐down approach : The nitration of phenol is an autocatalytic, strongly exothermic reaction and is thus difficult to handle on an industrial scale. Continuous nitration in a microreactor (see picture) affords higher yields and enhanced process safety, thanks to good heat exchange and mixing properties, as well as rapid radical propagation under sufficiently harsh conditions.