Premium
Stephacidin B, The Avrainvillamide Dimer: A Formidable Synthetic Challenge
Author(s) -
Escolano Carmen
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200502383
Subject(s) - enantioselective synthesis , aspergillus ochraceus , dimer , stereochemistry , chemistry , aspergillus , combinatorial chemistry , biology , organic chemistry , microbiology and biotechnology , mycotoxin , food science , ochratoxin a , catalysis
Rising to the challenge : Stephacidin B is an antitumor antibiotic isolated from the fungi Aspergillus ochraceus (see picture). Recently, two elegant approaches to the enantioselective synthesis of this dimeric N ‐hydroxyindole alkaloid were reported that pave the way to a series of medicinally attractive stephacidin analogues.