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Mass Spectrometric Profiling of Intact Biological Tissue by Using Desorption Electrospray Ionization
Author(s) -
Wiseman Justin M.,
Puolitaival Satu M.,
Takáts Zoltán,
Cooks R. Graham,
Caprioli Richard M.
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200502362
Subject(s) - desorption electrospray ionization , degree of unsaturation , chemistry , extractive electrospray ionization , mass spectrometry , electrospray ionization , desorption , electrospray , chromatography , direct electron ionization liquid chromatography–mass spectrometry interface , ionization , analytical chemistry (journal) , protein mass spectrometry , chemical ionization , organic chemistry , ion , adsorption
Direct chemical profiling of biological tissues, including metastatic human‐liver adenocarcinoma, was carried out by using mass spectrometry under ambient conditions. Desorption electrospray ionization revealed enhanced signals from sphingolipids and increased unsaturation levels of the phospholipids in the tumor region of the tissue (see picture).