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Rational Design of DNA Nanoarchitectures
Author(s) -
Feldkamp Udo,
Niemeyer Christof M.
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200502358
Subject(s) - supramolecular chemistry , rational design , nanotechnology , structural motif , dna , dna nanotechnology , computer science , materials science , chemistry , biology , genetics , crystallography , biochemistry , crystal structure
DNA has many physical and chemical properties that make it a powerful material for molecular constructions at the nanometer length scale. In particular, its ability to form duplexes and other secondary structures through predictable nucleotide‐sequence‐directed hybridization allows for the design of programmable structural motifs which can self‐assemble to form large supramolecular arrays, scaffolds, and even mechanical and logical nanodevices. Despite the large variety of structural motifs used as building blocks in the programmed assembly of supramolecular DNA nanoarchitectures, the various modules share underlying principles in terms of the design of their hierarchical configuration and the implemented nucleotide sequences. This Review is intended to provide an overview of this fascinating and rapidly growing field of research from the structural design point of view.