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Binding of Naphthyridine Carbamate Dimer to the (CGG) n Repeat Results in the Disruption of the G–C Base Pairing
Author(s) -
Peng Tao,
Nakatani Kazuhiko
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200502282
Subject(s) - triad (sociology) , dimer , cytosine , chemistry , carbamate , oligomer , piperidine , base pair , hydroxylamine , dna , stoichiometry , crystallography , stereochemistry , polymer chemistry , biochemistry , organic chemistry , psychology , psychoanalysis
A disruptive influence : The naphthyridine carbamate dimer ( NC ) binds to the CGG/CGG triad with an exclusive 2:1 stoichiometry. A DNA oligomer is selectively cleaved at the site of cytosine in the triad upon treatment of the NC ‐bound CGG/CGG triad with hydroxylamine and hot piperidine (see picture; red: 2‐amino‐1,8‐naphthyridine, blue: cytosine). The 2:1 NC ‐CGG/CGG complex is also produced in the (CGG) n repeat.