Oxindole Synthesis through Intramolecular Nucleophilic Addition of Vinylpalladiums to Aryl Isocyanates | Zendy

Kamijo Shin | Zendy; Sasaki Yuya | Zendy; Kanazawa Chikashi | Zendy; Schüßeler Thomas | Zendy; Yamamoto Yoshinori | Zendy

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Oxindole Synthesis through Intramolecular Nucleophilic Addition of Vinylpalladiums to Aryl Isocyanates

Author(s) -

Kamijo Shin,

Sasaki Yuya,

Kanazawa Chikashi,

Schüßeler Thomas,

Yamamoto Yoshinori

Publication year - 2005

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200502252

Subject(s) - organopalladium , intramolecular force , reactivity (psychology) , nucleophile , chemistry , oxindole , catalysis , aryl , medicinal chemistry , palladium , organic chemistry , medicine , alkyl , alternative medicine , pathology

Ringing the changes for organopalladium catalysts. A new nucleophilic reactivity of organopalladium species has been revealed. The reaction between aryl isocyanates and terminal alkynes in the presence of a palladium catalyst produces oxindoles through the intramolecular vinylpalladation of isocyanates (see scheme; dppe=1,2‐bis(diphenylphosphanyl)ethane).

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